Spread of Rams vs Cardinals and Over/Under Predictions and Picks

After being humiliated by the two top AFC title contenders in Week 1, the Los Angeles Rams and Arizona Cardinals regained victories in Week Two.

On Sunday, NFC West rivals will face off at State Farm Stadium in one of the best matches on the Week Three roster.

When they last met, the Rams choked the Cardinal in a wild card tour of the playoffs last season, beginning their run to the eventual Super Bowl title.

The defending champions looked a bit shaky to start this season, losing 31-10 to the Buffalo Bills in the opening game and almost snuffing out that goal last week against the Atlanta Falcons.

At the same time last week, the Cardinals looked destined for an ugly second straight loss to the West Asian rival after being defeated by the Kansas City Chiefs in the first week.

But after the Las Vegas Raiders trailed 20-0 at the end of the first half, Kyler Murray drove Arizona back to force overtime, as the cards made it happen with a scoop and Byron Murphy Jr.

With how tight NFC West is, head-to-head matches can be very important. So Sunday’s game at Glendale is important, even if it’s only Week 3.

Los Angeles Rams vs Arizona Cardinals Match info and betting odds

Match info

  • Match: Los Angeles Rams (1-1, second in the NFC West) vs. Arizona Cardinals (1-1, 4 in the NFC West)
  • Venue and location: State Farm Stadium (Glendale, Arizona)
  • Date: Sunday 25 September 2022
  • Playing time: 4:25 p.m. ET (1:25 p.m. local time)
  • How to watch Rams vs Cardinals: Fox

Rans vs. Cardinals Odds

Game odds via FanDuel. This article may also include odds from other legal sports betting sites that we recommend.


  • Rams Los Angeles -3.5 (-110)
  • Arizona Cardinals +3.5 (-110)

Above under

  • More than 48.5 (-110)
  • Under 48.5 (-110)

money line

  • Los Angeles Rams -194
  • Arizona Cardinals +162

Los Angeles Rams vs Arizona Cardinals Predictions & Picks

Predicting Rams vs Cardinals: Los Angeles to win

Choices for Rams vs. Cardinals: Los Angeles -3.5 (best value: -109 in BetRivers), Los Angeles/Arizona over 48.5 (best value: -110 in all of our recommended sportsbooks) and LA team over 26.5 (best value: -112 in FanDuel)

Sure, a win is a win, and the Rams needed to win after their failure against Buffalo in Week 1.

But there are some serious questions to ask about the Rams after they nearly blasted a 28-3 lead on their home ground against the Hawks. If they can gain an advantage against Arizona, they won’t be able to take their foot off the pedal against a team that has already shown they can come back from a major deficit.

But history is on the rams’ side in this.

The Cardinals haven’t won at home against their NFC West rivals since 2014. Since the 2017 season, Sean McVay’s first head coach, the Rams have scored more than 30 points on every trip to the desert.

  • 2017: Los Angeles 32, Arizona 16
  • 2018: Los Angeles 31, Arizona 9
  • 2019: Los Angeles 34, Arizona 7
  • 2020: Los Angeles 38, Arizona 28
  • 2021: Los Angeles 30, Arizona 23

Last season, the Rams went 7-2 and averaged 27.4 points per game on the road in the regular season. Of the seven wins, five were by four points or more, including each of their four wins over NFC teams.

It’s a new season, of course, and the defending champions clearly have some kinks they need to work out in the coming weeks. But they are still a better team than the Cardinals and will continue their impressive head-to-head run on Sunday.

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